RNA drugs lower lipoprotein(a) and genetically driven cholesterol

RNA drugs lower lipoprotein(a) and genetically driven cholesterol

-

Companies are deploying siRNA and antisense oligonucleotides to tackle dangerously high cholesterol driven by genetics, betting that a wider population will benefit.

How much Lp(a) circulates in a person’s bloodstream depends on their genes — diet and exercise have no impact. Targeting this molecule, therefore, could benefit a minority of patients who are born with elevated Lp(a), some of whom are otherwise healthy and with no other known cardiovascular risks. “This is like a genetic disease,” says Sekar Kathiresan, co-founder and CEO of Verve Therapeutics, who has published widely on the genetics of cardiovascular disease. Several development programs aimed at lowering Lp(a) particles are underway (Table 1).

Table 1 Lipoprotein(a)-lowering therapies in development

This is a preview of subscription content

Access options

Subscribe to Nature+

Get immediate online access to the entire Nature family of 50+ journals

Subscribe to Journal

Get full journal access for 1 year

$99.00

only $8.25 per issue

All prices are NET prices.

VAT will be added later in the checkout.

Tax calculation will be finalised during checkout.

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Author information

Authors and Affiliations

  1. Dublin, Ireland

    Cormac Sheridan

About this article

Verify currency and authenticity via CrossMark

Cite this article

Sheridan, C. RNA drugs lower lipoprotein(a) and genetically driven cholesterol.
Nat Biotechnol (2022). https://doi.org/10.1038/s41587-022-01396-x

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41587-022-01396-x

Read More

Latest news

India, France, UAE to work on climate change, biodiversity

India, France, UAE to work on climate change, biodiversity  The Associated Press - en Español...Read More

Reiterating the need for eco-friendly agriculture in India

Reiterating the need for eco-friendly agriculture in India  Hindustan Times...Read More

Indian watchdog tells investors markets stable despite Adani rout

Indian watchdog tells investors markets stable despite Adani rout  Reuters India...Read More

1500 players to take part in Khelo India Winter Games in Jammu and Kashmir: Thakur

1500 players to take part in Khelo India Winter Games in Jammu and Kashmir: Thakur  The Indian Express...Read More
- Advertisement -spot_img

First G20 Employment Working Group meet under India’s Presidency concludes | Mint

First G20 Employment Working Group meet under India’s Presidency concludes | Mint  Mint...Read More

WTF: Wacky Sifu action with Tai Chi magic too dangerous for TV

Sorry to be the bearer of bad news, kids. A group of adults that should know better...

Must read

- Advertisement -spot_imgspot_imgspot_imgspot_img

You might also likeRELATED
Recommended to you