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HomeUncategorizedResearchers Identify Genetic Mutation Responsible for Orange Coat in Domestic Cats

Researchers Identify Genetic Mutation Responsible for Orange Coat in Domestic Cats

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This mutation is located in the Rho GTPase Activating Protein 36 (Arhgap36) gene and appears to occur in no other mammal, according to a research team led by Stanford University School of Medicine scientists.

The sex-linked orange mutation in domestic cats causes variegated patches of reddish/yellow hair and is a defining signature of random X inactivation in female tortoiseshell and calico cats; unlike the situation for most coat color genes, there is no apparent homolog for sex-linked orange in other mammals; Kaelin et al. show that sex-linked orange is caused by a 5-kb deletion that leads to ectopic and melanocyte-specific expression of the Arhgap36 gene. Image credit: Kaelin et al., doi: 10.1016/j.cub.2025.04.055.

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This mutation is located in the Rho GTPase Activating Protein 36 (Arhgap36) gene and appears to occur in no other mammal, according to a research team led by Stanford University School of Medicine scientists.

The sex-linked orange mutation in domestic cats causes variegated patches of reddish/yellow hair and is a defining signature of random X inactivation in female tortoiseshell and calico cats; unlike the situation for most coat color genes, there is no apparent homolog for sex-linked orange in other mammals; Kaelin et al. show that sex-linked orange is caused by a 5-kb deletion that leads to ectopic and melanocyte-specific expression of the Arhgap36 gene. Image credit: Kaelin et al., doi: 10.1016/j.cub.2025.04.055.

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