81.1 F
New York
Wednesday, June 4, 2025
HomeUncategorizedResearchers Identify Genetic Mutation Responsible for Orange Coat in Domestic Cats

Researchers Identify Genetic Mutation Responsible for Orange Coat in Domestic Cats

Date:

This mutation is located in the Rho GTPase Activating Protein 36 (Arhgap36) gene and appears to occur in no other mammal, according to a research team led by Stanford University School of Medicine scientists.

The sex-linked orange mutation in domestic cats causes variegated patches of reddish/yellow hair and is a defining signature of random X inactivation in female tortoiseshell and calico cats; unlike the situation for most coat color genes, there is no apparent homolog for sex-linked orange in other mammals; Kaelin et al. show that sex-linked orange is caused by a 5-kb deletion that leads to ectopic and melanocyte-specific expression of the Arhgap36 gene. Image credit: Kaelin et al., doi: 10.1016/j.cub.2025.04.055.

Support authors and subscribe to content

This is premium stuff. Subscribe to read the entire article.

Subscribe

Gain access to all our Premium contents.
More than 100+ articles.

Buy Article

Unlock this article and gain permanent access to read it.

Related stories

New, Perfectly-Preserved Specimen of Archaeopteryx Discovered

Dubbed the Chicago Archaeopteryx, the new fossil is the...

Micah Parsons will attend minicamp, but what about training camp?

Cowboys edge rusher Micah Parsons will attend the team’s...

Jazz Chisholm Jr. homers in return to power Yankees to 3-2 win over Guardians

Carlos Rodon pitched seven one-run innings 6/4/2025, 1:50 AM Support authors...
spot_imgspot_imgspot_img

This mutation is located in the Rho GTPase Activating Protein 36 (Arhgap36) gene and appears to occur in no other mammal, according to a research team led by Stanford University School of Medicine scientists.

The sex-linked orange mutation in domestic cats causes variegated patches of reddish/yellow hair and is a defining signature of random X inactivation in female tortoiseshell and calico cats; unlike the situation for most coat color genes, there is no apparent homolog for sex-linked orange in other mammals; Kaelin et al. show that sex-linked orange is caused by a 5-kb deletion that leads to ectopic and melanocyte-specific expression of the Arhgap36 gene. Image credit: Kaelin et al., doi: 10.1016/j.cub.2025.04.055.

Support authors and subscribe to content

This is premium stuff. Subscribe to read the entire article.

Subscribe

Gain access to all our Premium contents.
More than 100+ articles.

Buy Article

Unlock this article and gain permanent access to read it.

Subscribe

- Never miss a story with notifications

- Gain full access to our premium content

- Browse free from up to 5 devices at once

Latest stories

spot_imgspot_imgspot_imgspot_img

LEAVE A REPLY

Please enter your comment!
Please enter your name here