IL-2 upgrades show promise at ASCO

IL-2 upgrades show promise at ASCO


Companies pursue souped-up IL-2 candidates, undeterred by Nektar’s setback.

Undeterred by bempegaldesleukin’s demise, the industry is forging ahead with a diverse pipeline of designer IL-2–based agents — more than a dozen of which are now in the clinic — as developers hope to overcome the challenges that have kept the cytokine from its immuno-oncology promise (Table 1). Many companies are eyeing applications in autoimmunity, too. “There are a lot of good strategies that are out there,” says Marc Ernstoff, chief of the ImmunoOncology Branch at the US National Cancer Institute. “Each of the engineered IL-2–like drugs is unique — and I think each will have to be tested.”

Table 1 IL-2 therapies in oncology trials

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  1. Somerville, MA, USA

    Elie Dolgin

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Dolgin, E. IL-2 upgrades show promise at ASCO.
Nat Biotechnol (2022).

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